Publications

Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

S.L. Teng, R. Latorre, D. Bhansali, P.K. Lewis, R.E. Pollard, C.J. Peach, B. Sokrat, G.S. Thanigai Arasu, T. Chiu, P. Duran, N.N. Jimenez-Vargas, A. Mocherniak, M. Bogyo, M.M. Gaspari, S.J. Vanner, N.M. Pinkerton, K. W. Leong, B.L. Schmidt, D.D. Jensen*, N.W. Bunnett*, PNAS. 122 (41) e2412687122.

Nanoparticle-Mediated Antagonism of Sustained Endosomal Signaling of the Calcitonin-like Receptor Provides Enhanced and Persistent Relief of Oral Cancer Pain

C.J. Peach, N.H. Tu, P.K. Lewis, R.E. Pollard, B. Sokrat, S. Nicholson, K. Trevett, N. Barrett, F. De Logu, J. Zhu, R. Latorre, S. Teng, M.J. Therien, D.D. Jensen, B.L. Schmidt, N.W. Bunnett, N.M. Pinkerton*, Biomaterials, 2026. 327, 123757

20 years of flash nanoprecipitation – from controlled precipitation to global medicine

K.D. Ristroph*, N.M. Pinkerton*, C.E. Markwalter, S.M. D'Addio, M.E. Gindy, R.F. Pagels, Advanced Drug Delivery Reviews, 2025. 227, 115700

A comparative study of flash nanoprecipitation and sequential nanoprecipitation: Impact of formulation parameters on drug-loaded nanoparticle formation

N.E. Amri, A. McKinstry, R.E. Pollard, P.K. Lewis, N.M. Pinkerton*, Mol. Pharmaceutics, 2025. 22, 10, 108-66119

Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP)

P.K. Lewis, N. El Amri, E.E. Burnham, N. Arrus, N.M. Pinkerton*, ACS Eng. Au, 2025. 5, 4, 468–477

Selected for the ACS Editor's Choice Collection.

Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil-Mediated Drug Delivery to in vitro Thrombi

S. Maiochi, E.E. Burnham, A. Cartay, V. Lisi, N. Beuchler, R.E. Pollard, D. Babaki, W. Bergmeier, N.M. Pinkerton*, E. Bahnson*, Advanced Healthcare Materials, 14 (15), 2404584 2025

Sequential nanoprecipitation for theranostics: Resolving assembly timescale mismatch in composite nanoparticle synthesis

R.E. Pollard, N. El Amri, P.K. Lewis, J.P. Ponce, A. Han, X. Li, N.M. Pinkerton, AIChE J. 2025. e18817

Design of Modular, 3D-Printed Millifluidic Mixers to Enable Sequential NanoPrecipitation (SNaP) for the Tunable Synthesis of Drug-Loaded Nanoparticles and Microparticles

T. Y. Belinky, N. E. Amri, P. K. Lewis, A. Karakosta LeMay, R. E. Pollard, N. M. Pinkerton*, Advanced Materials Technologies 2025. 10, 2400583

“Simple and Inexpensive Synthesis of Heterobifunctional Poly(Lactic Acid)-b-Poly(Ethylene Glycol) for Targeted Drug Delivery Applications” R.F. Pagels, N.M. Pinkerton, A.W. York, R.K. Prud’homme, Macromolecular Chemistry and Physics, 2020, 221, 1900396.

“Quench Ionic Flash Nanoprecipitation (qiFNP) as a Simple and Tunable Approach to Decouple Growth and Functionalization for the One-Step Synthesis of Functional LnPO4-Based Nanoparticles in Water” N.M. Pinkerton, K. Hadri, B. Amouroux, L. Behar, C. Mingotaud, M. Destarac, I. Kulai, S. Mazières, S. Chassaing, J.D. Marty, Chemical Communications, 2018, 54, 9438-9441.

“Photochemistry of ortho-Azidocinnamoyl Derivatives: Facile and Modular Synthesis of 2-Acylated Indoles and 2-Substituted Quinolines under Solvent Control” N.M. Pinkerton*, S. Chaabouni*, S. Abid, C. Galaup, S. Chassaing, Synlett, 2017, 19, 2614-2618. (*Equal contribution)

“Ionic Flash NanoPrecipitation for the Facile One-Step Synthesis of Inorganic-Organic Hybrid Nanoparticles in Water” N.M. Pinkerton, L. Behar, B. Amouroux, K. Hadri, C. Mingotaud, D.R. Talham, S. Chassaing, J.D. Marty, Nanoscale, 2017, 4, 1403-1408.

“Red-emitting EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models” N.M. Pinkerton*, C. Frongia, V. Lobjois, B.K. Wilson, M.J. Bruzek, R.K. Prud’homme, J. Anthony, F. Bolze, S. Chassaing*, RSC Advances, 2016, 6, 65770-65774.(*Corresponding author)

“Single-step assembly of multimodal imaging nanocarriers: MRI and long-wavelength fluorescence imaging” N.M. Pinkerton, M.E. Gindy, V.L. Calero-DdelC, R.F. Pagels, D. Adler, D. Gao, S. Li, M. Zevon, N. Yao, C. Pacheco, M.J. Therien, C. Rinaldi, P.J. Sinko, R.K. Prud’homme, Advanced Healthcare Materials, 2015, 4, 1376-1385.

“Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery” N.M. Pinkerton, S.W. Zhang, R.L. Youngblood, D. Gao, S. Li, J. Anthony, H.A. Stone, P.J. Sinko, R.K. Prud’homme, Biomacromolecules, 2014, 15, 252-261.

“Formation of stable nanocarriers by in situ ion pairing during block-copolymer-directed rapid precipitation” N.M. Pinkerton, A. Grandeury, A. Fisch, J. Brozio, B.U. Riebesehl, R.K. Prud’homme, Molecular Pharmaceutics, 2013, 10, 319-328.

“Initiated chemical vapor deposition (iCVD) of conformal polymeric nanocoatings for the surface modification of high aspect ratio pores” M. Gupta, V. Kapur, N.M. Pinkerton, and K.K. Gleason, Chemistry of Materials, 2008, 20, 1646-1651.

“1,5-Asymmetric induction during nucleophile additions to arenechromium tricarbonyl complexes, η6-{4-[[Spiro[(1R,2S)- 1,7,7- trimethylbicyclo[2.2.1]heptane-3.2′-[1,3]dioxolan]-2-yl]oxy]toluene}chromium tricarbonyl” H. Paramahamsan, A.J. Pearson, N.M. Pinkerton and A.A. Pinkerton, Acta Crystallographica Section C, 2008, 64, m147-m148.

Patents

"Composite Nanoparticles and Methods of Making Using Sequential Nanoprecipitation" Patent Application US 63/712,295: N.M Pinkerton, R.E. Pollard, N. El Amri, P.K. Lewis, 2024.

"Compositions and Methods for Treating Venous Blood Clots" Patent Application PCT/US2023/31542: S.L. Maiocchi, E.S.M. Bahnson, N.M. Pinkerton, 2023.

“Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations” Patent Application US 20200268679A1: R.K. Prud’homme, K.D. Ristroph, N.M. Pinkerton, H.D. Lu, P. Rummaneethorn, 2020.

“Lung targeting dual drug delivery system” Patent Number US 9421194: R.K. Prud’homme, P.J. Sinko, H.A. Stone, N.M. Pinkerton , L. Shi, J. Wan, S. Ibrahim, D. Gao, 2016.